Our bodies make digestive enzymes that break down food into nutrients that we can absorb. “The enzymes are secreted by the digestive tract starting in the mouth, but most digestive enzymes come from the pancreas,” says Kyle Staller, director of the Gastrointestinal Motility Laboratory at Massachusetts General Hospital. “This idea that we all have low-level digestive enzyme deficiency or that we could all benefit from a little boost doesn’t fit with our understanding of how the pancreas or enzymes work,” he notes.