Learn about Food Additives
Shopping was easy when most food came from farms. Now, factory-made foods have made chemical additives a significant part of our diet.
In general, it's best to avoid the following ingredients.
- Sodium nitrite
- Saccharin, Aspartame, Acesulfame-K
- Food Dyes
And don't forget to cut back on sugar and salt, which cause more harm than all the other additives combined.
Safety Ratings Key
Summary of the Safety of All Additives Print this chart
Artificial sweetener: Baked goods, chewing gum, gelatin desserts, diet soda, Sunette.
This artificial sweetener, originally manufactured by Hoechst, a giant German chemical company, is widely used around the world. It is about 200 times sweeter than sugar. In the United States, for several years acesulfame-K (the K is the chemical symbol for potassium) was permitted only in such foods as sugar-free baked goods, chewing gum, and gelatin desserts. In July 1998, the FDA allowed this chemical to be used in soft drinks, thereby greatly increasing consumer exposure. It is often used together with sucralose (see SUCRALOSE).
The safety tests of acesulfame-K were conducted in the 1970s and were of mediocre quality. Key rat tests were afflicted by disease in the animal colonies; a mouse study was several months too brief and did not expose animals during gestation. Two rat studies suggest that the additive might cause cancer. It was for those reasons that in 1996 the Center for Science in the Public Interest urged the FDA to require better testing before permitting acesulfame-K in soft drinks. In addition, large doses of acetoacetamide, a breakdown product, have been shown to affect the thyroid in rats, rabbits, and dogs. Hopefully, the small amounts in food are not harmful, but it needs to be better tested.
Preservative, flavoring, or acidulant.
Acetic acid is the chemical that gives vinegar its sharp taste and odor.
Acid, flavoring agent, antioxidant: soft drinks, fruit-flavored drinks, edible oils, gelatin desserts.
Adipic acid is sometimes used as the acid in bottled drinks and throat lozenges. Because it has little tendency to pick up moisture, adipic acid may be used to supply tartness, and it may account for the je ne sais quoi taste of highly manufactured powdered products, such as gelatin desserts and fruit flavored drinks. It is occasionally added to edible oils to prevent them from going rancid. Rats, and presumably humans, metabolize adipic acid without any difficulty.
Snack foods, ice cream, breakfast cereals
Air is by far the cheapest food additive, and perfectly safe. Extruded snack foods such as Cheetos, breakfast cereals like Kix, and inexpensive ice creams are fluffed out with air. In the ice cream world, the amount of air whipped into the final product is called overrun. Ben & Jerry's and Häagen-Dazs vanilla ice creams weigh more than 100 grams per half cup (120 grams), so they contain roughly 20% air. Breyers vanilla ice cream weighs 67 grams per half cup, with about 45% of the volume being air. That's one reason why the premium ice creams are higher in calories—they contain more actual ice cream per serving—and why the cheaper (and lower-calorie) ice creams are, well, cheaper.
Thickening agents, foam stabilizer: Ice cream, cheese, candy, yogurt, beer.
Alginate, an apparently safe derivative of seaweed (kelp), maintains the desired texture in dairy products, canned frosting, and other factory-made foods. Propylene glycol alginate, a chemically-modified algin, thickens acidic foods (soda pop, salad dressing) and can stabilize the foam in beer.
Antioxidant, nutrient: Vegetable oils, breakfast cereals, beverages.
Vitamin E is abundant in whole wheat, rice germ, and vegetable oils. It is destroyed by the refining and bleaching of flour. Vitamin E prevents oils from going rancid. Large amounts of vitamin E, such as from vitamin supplements, do not appear to provide any health benefit.
Bicarbonate, Carbonate, Chloride, Hydroxide, Phosphate, Sulfate: Decrease acidity, yeast food, leavening agents.
Ammonium compounds are sources of ammonia, which is used in the body to synthesize nitrogen-containing compounds and to adjust the acidity of bodily fluids, with an excess converted to urea and excreted in the urine. Ammonia is widely available in natural forms.
Amylases are enzymes that convert starch to sugar.
They occur naturally in plants, saliva, pancreatic juice, and microorganisms. Bakers add amylase to bread dough to supplement the small amount found naturally in wheat flour. The sugar that the amylases produce serves as food for the fermenting yeast and also makes for better-tasting, better-toasting bread. Amylases also improve the dough's consistency and the bread's keeping quality.
Natural coloring: butter, cheese, other foods.
Annatto is a widely used food coloring obtained from the seeds of a tropical shrub. Its hue is yellow to orange. Unfortunately, natural does not always mean perfectly safe. Annatto causes hives in some people. In fact, allergic reactions to annatto appear to be more common than reactions to commonly used synthetic food dyes.
Most artificially colored foods are colored with synthetic chemicals that do not occur in nature. Because colorings are used almost solely in foods of low nutritional value (candy, soda pop, gelatin desserts, etc.), you should simply avoid all artificially colored foods. In addition to problems mentioned below, colorings cause hyperactivity in some sensitive children. The use of coloring usually indicates that fruit or other natural ingredient has not been used. You can report adverse reactions to food dyes at cspinet.org/fooddyes.
Some foods are artificially colored with natural substances, such as beta-carotene and carmine. Please refer elsewhere in Chemical Cuisine for information about them.
Artificial Coloring: Beverages, candy, baked goods.
One (unpublished) animal test suggested a small cancer risk, and a test-tube study indicated the dye might affect neurons. It also causes occasional allergic reactions. Blue 1 might be safe for people who are not allergic, but it should be better tested.
Artificial Coloring: Pet food, beverages, candy.
Animal studies found some—but not conclusive—evidence that Blue 2 causes brain cancer in male rats, but the Food and Drug Administration concluded that there is "reasonable certainty of no harm.
Artificial Coloring: Skin of some Florida oranges only.
The amounts of this rarely used dye that one might consume, even from eating marmalade, are so small that the risk is not worth worrying about.
Artificial Coloring: Candy, beverages.
A 1981 industry-sponsored study gave hints of bladder and testes tumors in male rats, but FDA re-analyzed the data using other statistical tests and concluded that the dye was safe. Fortunately, this possibly carcinogenic dye is not widely used.
Artificial Coloring: Sausage.
Approved for use only in sausage casings, high doses of this dye are harmful to the liver and bile duct. However, that is not worrisome because Orange B has not been used for many years.
Artificial Coloring: Candy, baked goods.
The evidence that this dye caused thyroid tumors in rats is "convincing," according to a 1983 review committee report requested by FDA. FDA's recommendation that the dye be banned was overruled by pressure from the cherry industry and the U.S. Department of Agriculture. Red 3 used to color maraschino cherries, but it has been replaced there by the less controversial Red 40 dye. It is still used in a smattering of foods ranging from cake icing to fruit roll-ups to chewing gum.
Artificial Coloring: Soda pop, candy, gelatin desserts, pastries, pet food, sausage.
The most widely used food dye. While this is one of the most-tested food dyes, the key mouse tests were flawed and inconclusive. An FDA review committee acknowledged problems, but said evidence of harm was not "consistent" or "substantial." Red 40 can cause allergy-like reactions. Like other dyes, Red 40 is used mainly in junk foods.
Artificial Coloring: Gelatin dessert, candy, pet food, baked goods.
The second-most-widely used coloring causes allergy-like hypersensitivity reactions, primarily in aspirin-sensitive persons, and triggers hyperactivity in some children. It may be contaminated with such cancer-causing substances as benzidine and 4-aminobiphenyl (or chemicals that the body converts to those substances).
Artificial Coloring: Beverages, candy, baked goods.
Industry-sponsored animal tests indicated that this dye, the third-most-widely-used, causes tumors of the adrenal gland and kidney. In addition, small amounts of several carcinogens, such as 4-aminobiphenyl and benzidine (or chemicals that the body converts to those substances), contaminate Yellow 6. However, the FDA reviewed those data and found reasons to conclude that Yellow 6 does not pose a significant cancer risk to humans. Yellow 6 may cause occasional, but sometimes-severe, hypersensitivity reactions.
ARTIFICIAL AND NATURAL FLAVORING
Flavoring: Soda pop, candy, breakfast cereals, gelatin desserts, and many other foods.
Hundreds of chemicals are used to mimic natural flavors; many may be used in a single flavoring, such as for cherry soda pop. Most flavoring chemicals also occur in nature and are probably safe, but they are used almost exclusively in junk foods. Their use indicates that the real thing (often fruit) has been left out. Companies keep the identity of artificial (and natural) flavorings a deep secret. Flavorings may include substances to which some people are sensitive, such as MSG or HVP.
Artificial sweeteners are used in beverages, candies, chewing gum, yogurts, and many other products to provide sweetness without the calories. The question is: are they safe? Controversies have swirled around most of the additives. Sucralose, rebiana, and neotame appear to be safe, but acesulfame-potassium, aspartame, and saccharin may pose a slight risk of cancer (read about each ingredient elsewhere on this page). But research on all of them is relatively limited, especially considering how widely they are used, and surprises might occur. For instance, a 2010 study found that artificially sweetened drinks probably caused preterm deliveries; the researchers suspected that aspartame was the culprit (the study needs to be confirmed by other scientists). Synthetic "high-potency" sweeteners were the rule until about 2009 when rebiana, which is purified out of stevia leaves, became marketed widely in the United States. Rebiana, which has "taste challenges," allowed companies to claim for the first time "all natural" on their artificially sweetened (with a natural ingredient, that is) products.
Companies advertise their artificially sweetened foods as being almost magical weight-loss potions. The fact is, though, that losing weight is real hard, and people need to make a real concerted effort to eat fewer calories and exercise more. Artificial sweeteners can make the struggle a little more pleasant.
Antioxidant, nutrient, color stabilizer: Cereals, fruit drinks, cured meats.
Ascorbic acid—or vitamin C—helps maintain the red color of cured meat and prevents the formation of nitrosamines, which promote cancer (see SODIUM NITRITE). Vitamin C is also used to pump up the vitamin content of foods like "fruit" drinks and breakfast cereals. It also helps prevent loss of color and flavor in foods by reacting with unwanted oxygen. Though heroic amounts of ascorbic acid were recommended by Dr. Linus Pauling as a cure for common cold, subsequent research found only that it might slightly reduce the severity of colds.
Sodium ascorbate, also safe, is a more soluble form of ascorbic acid.
Ascorbyl palmitate is a fat-soluble antioxidant formed by combining ascorbic acid (vitamin C) with palmitic acid (derived from fat). Studies indicate that ascorbyl palmitate is completely metabolized, the ascorbic acid becoming available as vitamin C, and the palmitate portion is converted to energy or fat. Though palmitate from palm and other vegetable oils can increase blood cholesterol levels, the amount derived from this additive is trivial.
Artificial sweetener: "Diet" foods, including soft drinks, drink mixes, gelatin desserts, low-calorie frozen desserts, packets.
Aspartame (Equal, NutraSweet), a chemical combination of two amino acids and methanol, has been the focus of controversy since it was first used around 1980. Questions of cancer or neurological problems, such as dizziness or hallucinations, have swirled around aspartame for decades. A 1970s study initially sparked concerns that aspartame caused brain tumors in rats, but the U.S. Food and Drug Administration convinced an independent review panel to reverse its conclusion that aspartame was unsafe, and the agency approved its use.
The California Environmental Protection Agency and others have urged that independent scientists conduct new animal studies to resolve the cancer question. In 2005, researchers at the Ramazzini Foundation in Bologna, Italy, conducted the first such study. The study indicated that rats exposed to aspartame starting at eight weeks of age and continuing through their lifetime developed lymphomas, leukemias, and other tumors, including kidney tumors, which are extremely rare in the strain of rat used. In 2007, the same researchers published a follow-up study that began exposing rats to aspartame in utero. That study, too, found that aspartame caused leukemias/lymphomas, as well as mammary (breast) cancer. Then in 2010, they studied aspartame in mice, also exposing them beginning in utero. That third study found that aspartame caused liver and lung cancer in males.
Those new studies may have found problems that earlier company-sponsored studies did not because the Italian researchers monitored the animals for their lifetimes: as long as three years for the rats and 2.5 years for the mice, instead of just two years in the company-sponsored studies. Two-year-old rats are equivalent to roughly 65-year-old people. The many tumors that occurred after two years would never have been seen in industry's studies. Also, the company-sponsored cancer studies used fewer animals and thus were less sensitive in that regard. However, the food industry and the European Food Safety Authority hotly contested the Italian findings. The FDA said that the first study was flawed and that its scientists couldn't fully evaluate it because the researchers did not provide all their original data.
In defense of aspartame, industry points to a 2006 study by U.S. National Cancer Institute researchers. That study involved a large number of adults 50 to 71 years of age over a five-year period. There was no evidence that aspartame posed any risk. However, the study had three major limitations: It did not involve truly elderly people (the Italian studies monitored rodents until they died a natural death), the subjects had not consumed aspartame as children, and it was not a controlled study (the subjects provided only a rough estimate of their aspartame consumption, and people who consumed aspartame might have had other dietary or lifestyle differences that obscured the chemical's effects).
The bottom line is that three independent studies have found that consumption of aspartame causes cancer in rodents. However, the questions raised by government and industry reviewers about this important food additive can only be solved by new reliable, high-quality studies by other independent scientists.
Another wrinkle in the aspartame saga emerged in 2010, when Danish researchers linked the consumption of artificially sweetened, but not sugar-sweetened, soft drinks to preterm delivery of babies. Though the study couldn't distinguish between the various artificial sweeteners, aspartame and acesulfame-potassium are the most widely used. The authors suggest that the cause of the problem might be the methanol released when aspartame breaks down in the container or in the body. More research is needed on this issue. In the meantime, pregnant women might want to make a special effort to avoid consuming artificial sweeteners.
Since aspartame was first used, some people have contended that it causes headaches or dizziness. Anyone experiencing such problems should simply avoid aspartame.
See SODIUM BENZOATE
Coloring; nutrient: Margarine, shortening, non-dairy whiteners, beverages, breakfast cereals, supplements.
Beta-carotene is used as an artificial coloring and a nutrient supplement. The body converts it to Vitamin A, which is part of the light-detection mechanism of the eye and which helps maintain the normal condition of mucous membranes. Large amounts of beta-carotene in the form of dietary supplements increased the risk of lung cancer in smokers and did not reduce the risk in non-smokers. Smokers should certainly not take beta-carotene supplements, but the small amounts used as food additives are safe.
Natural high-potency sweetener
Brazzein has not yet been approved as a food additive, but food manufacturers see it as a better-tasting alternative to stevia-derived rebiana. Brazzein is a small (54 amino acids) protein molecule that occurs naturally in the berries of a climbing vine found in West Africa, where it has been consumed by people and animals. It is about 1,000 times sweeter than sugar, but, as far as we can determine, it has not been tested for safety. Because it is a protein, it might cause food allergies. One company is planning to market the sweetener under the name Cweet.
Emulsifier, clouding agent: Soft drinks.
BVO keeps flavor oils in suspension, giving a cloudy appearance to citrus-flavored soft drinks such as Mountain Dew, Fanta Orange, and Gatorade. Safety questions have been hanging over BVO since 1970, when the FDA removed BVO from its "Generally Recognized as Safe" list of food ingredients. In 1970, FDA permitted its use only an "interim" basis pending additional study—one of only four such interim-allowed additives. Decades later, BVO is still poorly tested and remains on the interim list.
Health concerns start with the finding that eating BVO leaves residues in body fat and the fat in brain, liver, and other organs. Animal studies indicate that BVO is transferred from mother's milk to the nursing infant and also can cause heart lesions, fatty changes in the liver, and impaired growth and behavioral development. Those studies suggest that BVO might be harmful to people who drink large amounts of soft drinks that contain BVO. Indeed, doctors have identified bromine toxicity in two people who drank extremely large amounts of such sodas. Sensitive, modern studies are urgently needed to better understand the risk, especially at the lower levels typically consumed by large numbers of children. Meanwhile, BVO should not be used (it is not permitted in Europe).
Antioxidant: Cereals, chewing gum, potato chips, vegetable oil.
BHA retards rancidity in fats, oils, and oil-containing foods. While some studies indicate it is safe, other studies demonstrate that it causes cancer in rats, mice, and hamsters. Those cancers are controversial because they occur in the forestomach, an organ that humans do not have. However, a chemical that causes cancer in at least one organ in three different species indicates that it might be carcinogenic in humans. That is why the U.S. Department of Health and Human Services considers BHA to be "reasonably anticipated to be a human carcinogen." Nevertheless, the Food and Drug Administration still permits BHA to be used in foods. This synthetic chemical can be replaced by safer chemicals (e.g., vitamin E), safer processes (e.g., packing foods under nitrogen instead of air), or can simply be left out (many brands of oily foods, such as potato chips, don't use any antioxidant).
Antioxidant: Cereals, chewing gum, potato chips, oils, etc.
BHT retards rancidity in oils. It either increased or decreased the risk of cancer in various animal studies. Residues of BHT occur in human fat. BHT is unnecessary or is easily replaced by safe substitutes (see discussion of BHA). Avoid it when possible.
Stimulant: Naturally occurring in coffee, tea, cocoa, coffee-flavored yogurt and frozen desserts. Additive in soft drinks, energy drinks, chewing gum, and waters.
Caffeine is one of only two drugs that are present naturally or added to widely consumed foods (quinine is the other drug used in foods). It is mildly addictive, one possible reason that makers of soft drinks add it to their products. Many coffee drinkers experience withdrawal symptoms, such as headaches, irritability, sleepiness, and lethargy, when they stop drinking coffee.
Because caffeine increases the risk of miscarriages (and possibly birth defects) and inhibits fetal growth, it should be avoided by women who are pregnant or considering becoming pregnant. It also may make it harder to get pregnant.
Caffeine also keeps many people from sleeping, causes jitteriness, and affects calcium metabolism. However, on the positive side, drinking a couple of mugs cups per day of regular (but not decaf) coffee appears to reduce the risk of Parkinson's disease, Alzheimer's disease, gallstones, and even suicide. It also can relieve headache pain, increase endurance, such as on a treadmill, and improve alertness.
The caffeine in a standard cup or two of coffee is harmless to most people. But be aware that a middle-size (16 oz.) cup of regular coffee at popular coffeehouses contains 300 or more milligrams of caffeine. That is equivalent to three old-fashioned 5-ounce-cups' worth of caffeine. A 12-oz. can of Coca-Cola or most other caffeinated soft drinks contains about 35 to 40 milligrams; energy drinks typically contain much more. Click here for a list of the caffeine content of beverages and foods. If you drink more than a couple of cups of coffee or several cans of caffeine-containing soda per day and experience insomnia or jitters, are at risk of osteoporosis, or are pregnant, you should rethink your habit.
Preservative: Bread, rolls, pies, cakes.
Calcium propionate prevents mold growth on bread and rolls. The calcium is a beneficial mineral; the propionate is safe. Sodium propionate is used in pies and cakes, because calcium alters the action of chemical leavening agents.
Dough conditioner, whipping agent: Bread dough, cake fillings, artificial whipped cream, processed egg whites.
These additives strengthen bread dough so it can be used in commercial bread-making machinery and help produce a more uniform grain and greater volume. They act as whipping agents in dried, liquid, or frozen egg whites and artificial whipped cream.
Coloring: Colas, baked goods, pre-cooked meats, soy and Worcestershire sauces, chocolate-flavored products, beer.
Caramel coloring is made by heating a sugar compound (usually high-dextrose corn syrup), often together with ammonium compounds, acids, or alkalis. It is the most widely used (by weight) coloring added to foods and beverages, with hues ranging from tannish-yellow to black, depending on the concentration and the food. Caramel coloring may be used to simulate the appearance of cocoa in baked goods, make meats and gravies look more attractive, and darken soft drinks and beer.
Caramel coloring, when produced with ammonia, contains contaminants, 2-methylimidazole and 4-methylimidazole. In 2007, studies by the U.S. National Toxicology Program found that those two contaminants cause cancer in male and female mice and possibly in female rats. In 2011, the International Agency for Research on Cancer, a division of the World Health Organization, concluded that 2- and 4-methylimidazole are "possibly carcinogenic to humans." Then, the State of California's Environmental Protection Agency listed ammonia-caramel coloring as a carcinogen under the state's Proposition 65. The state lists chemicals when they pose a lifetime risk of at least 1 cancer per 100,000 people. California warned that as of January 7, 2012, widely consumed products, such as soft drinks, that contained more than 29 micrograms of 4-methylimidazole per serving would have to bear a warning notice. In March 2012, when CSPI published the results of a study that found levels up to 150 micrograms per can of Coca-Cola and Pepsi-Cola purchased in Washington, DC, the soft-drink giants announced that they had reduced the contaminant to below California's threshold for action in products distributed in California. They said they would market the less-contaminated products throughout the country, but did not give a timetable for that change.
The FDA has a limit that is 10 times as strict as California's for regulating chemicals that are contaminated with cancer-causing chemicals. CSPI's analysis of a Coca-Cola purchased in 2012 in California found just 4 micrograms of 4-MI per 12 ounces. Even that much lower level might exceed the FDA's threshold for action of 1 cancer per million consumers.
It would be worth avoiding or drinking less colas and other ammonia-caramel-colored beverages not only because of risk from the 4-methylimidazole, but, of course, because the products contain about 10 teaspoons of sugar per 12 ounces and promote obesity and tooth decay. Soy sauces, baked goods, and other foods that contain ammoniated caramel coloring are much less of a problem, because the amounts consumed are small.
Carbon dioxide, a harmless gas, is responsible for the bubbles in beer, soda pop, mineral water, and the like.
CARBOXYMETHYLCELLULOSE (CMC, CELLULOSE GUM), SODIUM CARBOXYMETHYLCELLULOSE, CELLULOSE, AND RELATED COMPOUNDS
Improves texture, stabilizes foam (beer), prevents fruit from settling, prevents sugar from crystallizing (cake icings), binds water (used in diet foods): Ice cream, beer, pie fillings and jellies, cake icings, diet foods.
Cellulose is a safe and inexpensive carbohydrate that comprises the woody parts and cell walls of plants. Carboxymethylcellulose (CMC) is a safe thickening agent that is made by reacting cellulose (wood pulp, cotton lint) with a derivative of acetic acid (the acid in vinegar). It is also called cellulose gum.
CMC is not absorbed or digested, so it might be included in with "dietary fiber" on food labels (it isn't as healthful as fiber obtained from natural foods).
Cochineal extract is a coloring obtained from the cochineal insect, which lives on cactus plants in Peru, the Canary Islands, and elsewhere. Carmine is a more purified coloring made from cochineal, but in both cases, carminic acid actually provides the color. These colorings, which are extremely stable, are used in some red, pink or purple candy, yogurt, ice cream, beverages, and other foods, as well as in drugs and cosmetics. They appear to be safe, except that a small percentage of consumers suffer allergic reactions ranging from hives to life-threatening anaphylactic shock. Carmine and cochineal have long been listed on labels simply as "artificial coloring" or "color added." In 2009, in response to a petition by the Center for Science in the Public Interest, the U.S. Food and Drug Administration gave the food industry until January 1, 2011, to clearly identify the colorings as carmine or cochineal extract on food labels to help consumers identity the cause of their allergic reaction and avoid the colorings in the future. Unfortunately, sensitive individuals must endure any number of allergic reactions before identifying the cause. The FDA rejected CSPI's request for labels to disclose that carmine is extracted from insects so vegetarians and others who want to avoid animal products could do so.
Thickening, gelling, and stabilizing agent: Ice cream, jelly, chocolate milk, infant formula, cottage cheese.
Carrageenan is an indigestible family of large molecules obtained from seaweed. Large amounts of carrageenan have harmed test animals’ colons; the small amounts in food are safe.
Thickening and whitening agent: Ice cream, ice milk, sherbet, coffee creamers.
Casein, the principal protein in milk, is a nutritious protein containing adequate amounts of all the essential amino acids. People who are allergic to casein should read food labels carefully, because the additive is used in some non-dairy and vegetarian foods.
Natural flavoring: vanilla-flavored and other foods
This substance is occasionally used as a natural flavoring. Only about 1,000 pounds of the product are used annually, so it really isn't a significant part of the food supply, nor should it pose any risk. The FDA considers it to be "generally recognized as safe." But because it is extracted from the anal castor sacs of beavers, it has been publicly lampooned in recent years.
Beavers mix castoreum with urine to mark their territories and make their fur and tail more water-resistant. The food industry finds it strong, tar-like, musky odor to be useful in flavorings. Of course, you'll never see "castoreum from anal sacs of beavers" on food labels; instead, it is just included in the broad term "natural flavorings."
Acid, flavoring, chelating agent: Ice cream, sherbet, fruit drink, candy, carbonated beverages, instant potatoes.
Citric acid is versatile, widely used, cheap, and safe. It is an important metabolite in virtually all living organisms and is especially abundant naturally in citrus fruits and berries. It is used as a strong acid, a tart flavoring, and an antioxidant. Sodium citrate, also safe, is a buffer that controls the acidity of gelatin desserts, jam, ice cream, candy, and other foods.
Sweetener, thickener: Candy, marshmallows, syrups, snack foods, imitation dairy foods.
Corn syrup, which consists mostly of dextrose, is a sweet, thick liquid made by treating cornstarch with acids or enzymes. It may be dried and used as corn syrup solids in coffee whiteners and other dry products. Corn syrup contains no nutritional value other than calories, promotes tooth decay, and is used mainly in foods with little intrinsic nutritional value.
Artificial sweetener: Diet foods.
This controversial high-potency sweetener was used in the United States in diet foods until 1970, at which time it was banned. Animal studies indicated that it causes cancer. Now, based on animal studies, it (or a byproduct) is believed not to cause cancer directly, but to increase the potency of other carcinogens and to harm the testes.
Cysteine, an amino acid, is a natural constituent of protein-containing foods. It is added to foods to prevent oxygen from destroying vitamin C. Bakers use cysteine to reduce the mixing time for dough.
Emulsifier: Bread, biscuits.
This safe emulsifier is used to build a strong gluten network to improve bread volume and keep dough from getting sticky or collapsing.
Emulsifier: Prevents sugar from crystallizing, encapsulates flavor oils, thickening agent: Candy, powdered mixes.
Dextrin is the mixture of fragments that results from treating starch with acid, alkali, or enzymes. It is as safe as starch.
Sweetener: Bread, caramel, soda pop, cookies, many other foods.
Dextrose is an important chemical in every living organism. A sugar, it is a source of sweetness in fruits and honey. Added to foods as a sweetener, it represents empty calories and contributes to tooth decay. Dextrose turns brown when heated and contributes to the color of bread crust and toast. Dextrose contributes a modest amount of the 98 pounds of refined sugars that the average American consumes annually.
Diacetyl is one of the many chemicals that give butter its characteristic flavor. Low levels are present in butter (including unsalted butter, to which extra diacetyl is added to prolong its shelf life). Much higher levels have been used in butter-flavored popcorn, margarine, and butter-flavored cooking oils and sprays. The low levels are safe, but workers in factories that produce microwave popcorn learned the hard way that long-term exposure to diacetyl causes obstructive lung disease, which is potentially fatal. Following widespread publicity around 2005 to 2007 and several lawsuits persuaded most major American food manufacturers to protect their workers (and restaurant cooks) by switching to safer ingredients.
This is the diglyceride part of the long-used emulsifier, mono- and diglycerides. The manufacturer claims that it can help people lose weight and reduce triglyceride levels. Don't count on this little-used ingredient providing any real benefit.
Chelating agent: Salad dressing, margarine, sandwich spreads, mayonnaise, processed fruits and vegetables, canned shellfish, soft drinks.
Modern food-manufacturing technology, which involves rollers, blenders, and containers made of metal, results in trace amounts of metal contamination in food. EDTA (ethylenediamine tetraacetic acid) traps metal impurities, which would otherwise promote rancidity and the breakdown of artificial colors. It is safe.
Antioxidant, color stabilizer: Cured meats.
See ASCORBIC ACID
Non-caloric sweetener: Low-calorie drinks, hard candy, chocolate milk, frozen desserts, baked goods, table-top sweeteners (mixed with rebiana)
This sugar alcohol, which was first used commercially in the United States in about 2001, is about 70 percent as sweet as sugar. It occurs naturally in such fruits as pears, melons, and grapes, but virtually all of the erythritol used as a food additive is produced by fermenting glucose with various yeasts. Erythritol's virtues are its sweetness and its indigestibility—it provides only one-twentieth as many calories as sugar. Many companies mix it with high-potency sweeteners, such as rebiana (from stevia), aspartame, and sucralose, to keep the calories down while masking those other sweeteners' unpleasant after-tastes. Companies also value erythritol because it provides the bulk that sugar, but not high-potency sweeteners, has, and it adds to the "mouthfeel" of sugar-sweetened beverages. Because it is not digested by bacteria, it does not promote tooth decay.
Other than occasional allergic reactions, the only safety concern about erythritol is that eating too much of it could cause nausea. Most adults can safely consume up to about 50 grams of erythritol per day, which might be provided by about five 12-ounce soft drinks or 50 teaspoons of a sugar substitute made with rebiana (but individual sensitivities vary greatly). That's safer than sorbitol, mannitol, and lactitol. Erythritol's relative safety is due to its being mostly absorbed into the bloodstream and excreted unchanged in urine. Other sugar alcohols stir up trouble in the colon where they attract water (leading to laxation or diarrhea) or are digested by bacteria (causing gas).
Coloring, nutrient: Black olives.
Used by the olive industry to generate a uniform jet-black color and in pills as a source of iron.
See STARCH, MODIFED
Sweetener: "Health" drinks and other products.
Fructose (also called levulose) is a sugar that is a little sweeter than table sugar. Modest amounts of fructose occur naturally in fruits and vegetables, which also contain other sugars. When table sugar is digested, it breaks down into equal amounts of fructose and glucose (dextrose). Another major source of fructose in the typical diet is high-fructose corn syrup (HFCS), which typically contains about half fructose and half glucose. Fructose itself is used as a sweetener in a small number of foods whose labels often imply, deceptively, that such foods are healthier than competing products that are sweetened with sugar or HFCS.
The fructose that occurs in fruits and vegetables is certainly safe. However, the large amounts that come from added fructose, sucrose (ordinary table sugar), and high-fructose corn syrup increase triglyceride (fat) and small, dense LDL ("bad") cholesterol levels in blood and may thereby increase the risk of heart disease. Also, recent studies show that consuming 25 percent of one's calories from fructose or high-fructose corn syrup (which is about half fructose) leads to more visceral (deep belly) fat or liver fat. Those changes may increase the risk of diabetes and heart disease. Finally, large amounts consumed on a regular basis also may affect levels of such hormones as leptin and ghrelin, which help regulate appetite, thereby contributing to weight gain and obesity.
The Dietary Guidelines for Americans (America's basic nutrition policy), American Heart Association, and other health authorities recommend that people consume no more than about 3 to 8 percent of calories in the form of refined sugars. That's far less than the current average of 14 percent of calories. The bottom line: the less added sugars—fructose, dextrose, sucrose, or HFCS—one consumes the better (though, again, small amounts are safe).
Tartness agent: Powdered drinks, pudding, pie fillings, gelatin desserts.
A solid at room temperature, inexpensive, and highly acidic, fumaric acid is the ideal source of tartness and acidity in dry food products. However, it dissolves slowly in cold water, a drawback cured by adding DIOCTYL SODIUM SULFOSUCCINATE (DSS), a detergent-like additive that appears to be safe.
Thickening and gelling agent: Powdered dessert mixes, marshmallows, yogurt, ice cream, cheese spreads, beverages.
Gelatin is a protein obtained from animal hides and bones. It has little nutritional value, because it contains little or none of several essential amino acids.
Pretend benefits: Beverages.
Companies add small amounts of Ginkgo biloba to beverages because it supposedly boosts memory and thinking, but most studies in healthy people show little or no benefit at levels greater than what's added to foods and beverages. Since ginkgo appears to interfere with blood clotting, ginkgo should not be consumed before or after surgery, during labor and delivery, or by those with bleeding problems such as hemophilia. Importantly, in 2013, the U.S. Government's National Toxicology Program published the first study that could evaluate Ginkgo's ability to cause cancer. The study found "clear evidence" that Ginkgo biloba caused liver cancer in male and female mice and "some evidence" that Ginkgo caused thyroid cancer in rats.
Pretend benefits: Energy drinks.
Companies add small amounts to foods because of ginseng's reputation for boosting energy, sexual stamina, and mental effort, but there's little evidence for those claims even at much higher levels than what is found in foods. The amount in foods and beverages is not likely to pose a safety risk.
Sequestrant, acidifier, leavening agent, curing agent: Nonalcoholic beverages, processed fruit and fruit juices, baked goods, dairy products, cured meats.
Gluconic acid is a metabolite of glucose. Glucono delta-lactone is the most widely used of this family of compounds and is used to adjust the acidity or as a leavening agent in baked goods, processed fruits, and dairy products. It is also used in some cured meats to speed the formation of the pink color.
All of these substances are quite safe. See also ferrous gluconate.
Maintains water content: Candy, fudge, baked goods.
In nature, glycerin forms the backbone of fat and oil molecules. The body uses it as a source of energy or as a starting material in making more-complex molecules.
Flavor enhancer: Soups, sauces, seasonings.
GMP and inosine monophosphate (IMP) are used together to enhance the meaty (umami) flavor of soups and other foods. They are usually used together with monosodium glutamate (MSG), because they enhance its potency.
Stimulant: Energy drinks, teas.
Guarana is a plant that has seeds high in caffeine. Companies add guarana to beverages as a "natural" source of caffeine, but its effect is the same as the caffeine in coffee or tea. Include guarana when you're keeping track of the caffeine in your diet. Too much caffeine from any source can cause insomnia, anxiety, and other problems (see discussion of caffeine).
Arabic, Furcelleran, Ghatti, Guar, Karaya, Locust Bean, Tragacanth, Xanthan.
Thickening agents, stabilizers: Beverages, ice cream, frozen pudding, salad dressing, dough, cottage cheese, candy, drink mixes.
Gums are derived from natural sources (bushes, trees, seaweed, bacteria) and are poorly tested, though probably safe. They are not absorbed by the body. They are used to thicken foods, prevent sugar crystals from forming in candy, stabilize beer foam (arabic), form a gel in pudding (furcelleran), encapsulate flavor oils in powdered drink mixes, or keep oil and water mixed together in salad dressings. Gums are often used to replace fat in low-fat ice cream, baked goods, and salad dressings. Tragacanth has caused occasional severe allergic reactions. The FDA warns against giving a product called SimplyThick, which contains xanthan gum, to infants, since it may cause a life-threatening condition called necrotizing enterocolitis. It is not clear whether the gum itself, bacterial contamination of the gum, or some other cause is to blame.
Inert, safe gas: Balloons or pressurized containers.
Helium is an inert, safe gas that is used to float balloons or sometimes to force foods out of pressurized containers.
Preservative: Beer, non-carbonated soft drinks.
Heptyl paraben—short for the heptyl ester of para-hydroxybenzoic acid—is a preservative. Studies suggest that this rarely used additive is safe, but it, like other additives in alcoholic beverages, has never been tested in the presence of alcohol (such as in animals weakened by long-term consumption of alcohol).
Sweetener: Soft drinks, other processed foods.
Our consumption of high-fructose corn syrup (HFCS) has soared since around 1980. That's because this sweet syrupy liquid is cheaper and easier for some companies to use than sugar. HFCS has been blamed by a few people for the obesity epidemic, because rates of obesity have climbed right along with HFCS consumption. But that's an urban myth. HFCS and sugar are equally harmful. We're consuming way too much of both.
HFCS starts out as cornstarch. Companies use enzymes or acids to break down most of the starch into its glucose subunits. Then other enzymes convert different proportions of the glucose to fructose. The resulting syrups contain as much as 90 percent fructose, but most HFCS is 42 percent or 55 percent fructose. In 2011, about 48 pounds of corn sweeteners, mostly HFCS, and 70 pounds cane and beet sugar were produced per capita in the United States. A total of 134 pounds of all caloric sweeteners, down 13 percent from the 1999 high of 154 pounds, was produced per person. And, because of all the criticism (not fully deserved) of HFCS in recent years, HFCS consumption declined by about 22 percent between 2002 and 2010. Much of that historic decline resulted from declining soft drink consumption (thanks to increased health consciousness and to the popularity of bottled water). Actual consumption (as opposed to production) of caloric sweeteners, according to the U.S. Department of Agriculture, was 79 pounds per person in 2011.
Some people think that HFCS is mostly fructose, which probably plays a significant role in obesity. However, HFCS, on average, is about half fructose and half glucose—the same as ordinary table sugar (sucrose) when it is metabolized by the body. When sugar is (or, as is generally the case, was) used in soft drinks, much of it is broken down to glucose and fructose right in the bottle.
Some people have contended that soft drinks made with HFCS are cheaper than if they were made with regular sugar. However, the extra cost would only be at most a penny or two per can, a difference that would have little effect on consumption.
Modest amounts of fructose from HFCS or other sources are safe and do not boost blood glucose levels, making the sweetener attractive to diabetics. However, large amounts promote tooth decay, as well as increase triglyceride (fat) levels in blood, thereby increasing the risk of heart disease. Also, recent studies show that consuming 25 percent of calories from fructose or HFCS leads to more visceral (deep belly) fat or liver fat. Those changes may increase the risk of diabetes or heart disease. Finally, large amounts of fructose consumed on a regular basis also may affect levels of such hormones as insulin, leptin, and ghrelin that regulate appetite, thereby contributing to weight gain and obesity. The HFCS 55 that is used in most soft drinks contains about 10 percent more fructose than sucrose. That makes most soft drinks a bit more harmful than if they were made with sugar.
The Dietary Guidelines for Americans (America's basic nutrition policy), American Heart Association, and other health authorities recommend that people consume no more than about 3 to 8 percent of calories in the form of refined sugars. That's far less than the current average of 15 percent of calories. The bottom line: the fewer added sugars—fructose, sucrose, or HFCS—one consumes the better (though, again, small amounts are safe).
Improves shelf life, inhibits bacterial growth, fermentation, other purposes: Candy, baked goods, beer.
Acids or enzymes are used to break down cornstarch into a syrup rich in maltose (35 percent or more), a disaccharide. High maltose corn syrup, corn syrup solids, and maltodextrin are similar, and each are produced in a wide variety of formulations for different applications.
Sweetener: Dietetic and reduced-calorie foods.
HSH, like sorbitol, is slightly sweet and poorly absorbed by the body. Like sorbitol, and other sugar alcohols, eating significant amounts of HSH may cause intestinal gas and diarrhea.
Flavor enhancer: Instant soups, frankfurters, sauce mixes, beef stew.
HVP consists of vegetable (usually soybean) protein that has been chemically broken down to the amino acids of which it is composed. HVP is used to bring out the natural flavor of food (and, perhaps, to enable companies to use less real food). It contains MSG and may cause adverse reactions in sensitive individuals.
Flavor enhancer: Soups, sauces, seasonings.
IMP and guanosine monophosphate (GMP) are used together to enhance the meaty (umami) flavor of soups and other foods. They are often used together with monosodium glutamate (MSG), because they enhance its potency. These safe 5'-ribonucleotides are produced together.
Fiber and fat substitute: Margarine, baked goods, fillings, dairy foods, frozen desserts, salad dressing.
It's a naturally occuring soluble fiber. Inulin doesn't raise blood sugar levels, so it may help people with diabetes. It also stimulates the growth of friendly bacteria in the large intestine.
Sweetener: Candy, soft drinks, many other foods.
Invert sugar, a 50-50 mixture of two sugars, dextrose and fructose, is sweeter and more soluble than sucrose (table sugar). Invert sugar forms when sucrose is split in two by an enzyme or acid. It provides "empty calories," contributes to tooth decay, and should be avoided.
Isolated soy protein is simply protein purified from soybeans. Textured vegetable protein is soy protein that has been combined with chemical additives and processed into granules, chunks, or strips that resemble meat. These proteins are used in some imitation meat products, which are generally healthful, but may contain flavor enhancers, thickening agents, emulsifiers, and artificial colorings.
Sugar substitute: Hard candies, chewing gum, baked goods, chocolates.
This slightly sweet ingredient is manufactured from sugar and does not promote tooth decay. It is often mixed with artificial sweeteners, such as sucralose, to provide more sweetening power. Isomalt is poorly absorbed by the body, which means it has only half the calories of sugar. Chemically, it is a disaccharide sugar-alcohol consisting of glucose and mannitol or sorbitol sub-units. Like many other sugar alcohols, large amounts can cause diarrhea.
Controls acidity: Spanish olives, cheese, frozen desserts, carbonated beverages.
This safe acid occurs in almost all living organisms. It inhibits spoilage in Spanish-type olives, balances the acidity in cheese-making, and adds tartness to frozen desserts, carbonated fruit-flavored drinks, and other foods.
Sweetener: Candy, chocolates, baked goods, ice cream, and other sugar-free foods.
Lactitol, like sorbitol, mannitol, and xylitol, is a sugar alcohol, also called a polyol. It is made from lactose, or milk sugar. Like other sugar alcohols, lactitol is not absorbed well by the body (which means it has fewer calories per gram than table sugar) and does not promote tooth decay. However, large amounts (above 20 to 30 grams) may cause loose stools or diarrhea.
Nutrient, sweetener: Whipped topping mix, fortified breakfast pastry.
Lactose, a carbohydrate that is found only in milk, is nature's way of delivering calories to infant mammals. One-sixth as sweet as sugar, it is used as a slightly sweet source of carbohydrate. The intestine secretes an enzyme that splits lactose into its two principal sugars: glucose and galactose. Children suffering from galactosemia, a rare genetic disease, can suffer serious harm by consuming lactose. Far more common is ‘lactose intolerance', where undigested lactose is metabolized by bacteria, producing gas, bloating, and flatulence. Most Orientals and people of black African heritage cannot tolerate as much lactose as Caucasians after early childhood. Some people are acutely lactose intolerant, but most people with lactose intolerance can safety eat smaller amounts of dairy products or foods with added lactose.
Emulsifier, antioxidant: Baked goods, margarine, chocolate, ice cream.
A common constituent of animal and plant tissues, lecithin is a source of the nutrient choline. It keeps oil and water from separating out, retards rancidity, reduces spattering in a frying pan, and leads to fluffier cakes. Major natural sources are egg yolk and soybeans.
Sweetener: Candy, chocolates, jams, and other sugar-free foods.
Maltitol, like sorbitol, mannitol, and xylitol, is a sugar alcohol, also called a polyol. It is made by hydrogenating maltose, which is obtained from corn syrup. Like other sugar alcohols, mannitol is not absorbed well by the body (which means it has fewer calories per gram than table sugar) and does not promote tooth decay. However, large amounts (above 20 to 30 grams) may have a laxative effect.
Carbonate, Chloride, Hydroxide, Phosphate, Stearate, Sulfate: Anticaking agent, alkali, nutrient, water corrective.
Magnesium is a mineral that is a crucial component of many enzymes in the human body and plays a unique role in muscle contraction. We get about half our magnesium from nuts, beans, whole grains, fruits, and vegetables, but it's also in many other foods. About half of the body's magnesium is stored in bone.
Acidulant, flavoring: Fruit-flavored drinks, candy, lemon-flavored ice-tea mix, ice cream, preserves.
L-Malic acid is an important metabolite present in all living cells and is abundant in apples. It is sometimes called "apple acid." The food industry uses malic acid as an acidulant and flavoring agent in fruit-flavored drinks, candy, lemon-flavored ice-tea mix, ice cream, and preserves.
While adults can probably utilize D-malic acid (the unnatural form), infants may not, so synthetic DL-malic acid should not be added to baby food.
Texturizer in processed foods.
This ingredient is made from starch and consists of short chains of glucose molecules. Normal maltodextrins are easily digested and absorbed by the body. But companies also use "resistant maltodextrin" to simulate dietary fiber. That form of maltodextrin is made by treating starch with enzymes, heat, or acids and cannot be broken down by digestive enzymes. That makes the additive an "isolated fiber." Resistant maltodextrins may help lower blood sugar levels, but don't help prevent constipation.
Maltodextrin is usually made from starch from corn, potato, or rice, but is sometimes made from wheat starch. If maltodextrin is made from wheat, food labels will indicate that fact to protect people who are allergic to wheat.
Sweetener, other uses: "Dust" on chewing gum, low-calorie foods.
Mannitol, like sorbitol and xylitol, is a sugar alcohol, also called a polyol. Like other sugar alcohols, mannitol is not as sweet as sugar, not absorbed well by the body (which means it provides only half as many calories per gram as table sugar), and does not promote tooth decay. However, large amounts may have a laxative effect and even cause diarrhea. The FDA requires foods "whose reasonably foreseeable consumption may result in a daily ingestion of 20 grams of mannitol" to bear this mild warning: "Excess consumption may have a laxative effect."
Natural high-potency sweetener: frozen desserts, other sweet foods. Also called monkfruit, Swingle fruit extracts (SGFE), Luo Han Guo, Lo Han Kuo.
This sweetener is about 200 times sweeter than sugar (sucrose), meaning that it (like artificial sweeteners and extracts of stevia called rebaudiosides) can be used to replace some or all of the added sugars in a wide range of foods and beverages. This product has not been well tested in animals, though, as a natural ingredient in a fruit that has been used as food in China for at least several hundred years and as an herbal medicine for the past several decades, it may well be perfectly safe. The fruit extracts contain several intensely sweet substances, all complex organic terpenoid molecules, with one company's purest product containing more than 50 percent mogroside V. The plant is a vine that grows in southern China. It may have what may be euphemistically called a lingering "licorice-like" after-taste. Labels may call the ingredient monkfruit, but don't think you're getting a bit of whole fruit; manufacturers use a multi-step process to extract just the sweet mogrosides.
Natural high-potency sweetener
Monatin is not yet used as a food additive, but Cargill, PepsiCo, and other companies see it as a possibility in the future. Like stevia-derived rebiana, monatin comes from a plant—in this case the root bark of shrub that grows in South Africa, where the plant has been consumed by people. The substance, which can be manufactured in a factory, is about 3,000 times sweeter than sugar and supposedly does not have the unpleasant aftertaste that rebiana has. Monatin has undergone only rudimentary safety testing.
Emulsifier: Baked goods, margarine, candy, peanut butter.
Makes bread softer and prevents staling, improves the stability of margarine, makes caramels less sticky, and prevents the oil in peanut butter from separating out. Mono- and diglycerides are safe, though most foods they are used in are high in refined flour, sugar, or fat.
Flavor enhancer: Soup, salad dressing, chips, frozen entrees, restaurant foods.
This amino acid brings out the flavor in many foods. While that may sound like a treat for taste buds, the use of MSG allows companies to reduce the amount of real ingredients in their foods, such as chicken in chicken soup. In the 1960s, it was discovered that large amounts of MSG fed to infant mice destroyed nerve cells in the brain. After that research was publicized, public pressure forced baby-food companies to stop adding MSG to their products (it was used to make the foods taste better to parents).
Careful studies have shown that some people are sensitive to large amounts of MSG. Reactions include headache, nausea, weakness, and burning sensation in the back of neck and forearms. Some people complain of wheezing, changes in heart rate, and difficulty breathing. Some people claim to be sensitive to very small amounts of MSG, but no good studies have been done to determine just how little MSG can cause a reaction in the most-sensitive people. To protect the public's health, manufacturers and restaurateurs should use less or no MSG and the amounts of MSG should be listed on labels of foods that contain significant amounts. People who believe they are sensitive to MSG should be aware that other ingredients, such as natural flavoring and hydrolyzed vegetable protein, also contain glutamate. Also, foods such as Parmesan cheese and tomatoes contain glutamate that occurs naturally, but no reactions have been reported to those foods.
Meat substitute: Quorn brand foods.
Mycoprotein, the novel ingredient in Quorn-brand frozen meat substitutes, is made from processed mold (Fusarium venenatum). Though the manufacturer's (Marlow Foods) advertising and labeling implied that the product is "mushroom protein" or "mushroom in origin," the mold (or fungus) from which it is made does not produce mushrooms. Rather, the mold is grown in liquid solution in large tanks. It has been used in the United Kingdom since the 1990s and has also been sold in continental Europe. Quorn foods have been marketed in the United States since 2002. The chunks of imitation meat are nutritious, but the prepared foods in which they are used may be high in fat or salt.
Several percent of consumers are sensitive to Quorn products, resulting in vomiting, nausea, diarrhea, and, less often, hives and potentially fatal anaphylactic reactions. Many people have gone to emergency rooms for treatment of Quorn-related reactions. A survey in the United Kingdom sponsored by the Center for Science in the Public Interest (CSPI) found that the percentage of consumers sensitive to Quorn is probably as great as, or greater than, the percentage sensitive to soy, milk, peanuts, and other common food allergens. The British and American governments acknowledge that Quorn foods cause allergic reactions, but rejected CSPI's recommendations to bar the use of mycoprotein or require Quorn foods to bear a warning label. (In fact, when Quorn-containing "vegetarian" products are served at restaurants, cafeterias, and other foodservice locations, there is no label to inform consumers that they are eating Quorn foods.)
Consumers who believe they have been sickened by Quorn foods may file a report with the Center for Science in the Public Interest.
This antimicrobial agent is produced by bacteria and used to prevent mold growth in cheese.
Artificial sweetener: Diet soft drinks and other diet foods.
Neotame, produced by NutraSweet Co. (maker of aspartame), is about 8,000 times sweeter than table sugar and 40 times sweeter than aspartame. Neotame is chemically related to aspartame, but the difference confers greater chemical stability, enabling the new sweetener to be used in baked foods. It likely will be used mostly in low-calorie foods, but may also be used to adjust the flavor of other foods. Neotame is often mixed with sugar or other artificial sweeteners. It was approved by the U.S. FDA in 2002 and the European Union in 2010, but is still rarely used.
Nutrient: Enriched flour, breakfast cereals, and other fortified foods.
Niacin, or vitamin B3, is safe. Niacin deficiency causes pellagra, which is characterized by mental disturbances and potentially death.
Preservative: meat and poultry products, cheese, liquid eggs, salad dressings
Nisin is a short polypeptide (small protein molecule) that is produced by lactic acid bacteria and has anti-bacterial properties. It is unclear how widely this preservative is used.
Nitrous oxide is often used as the propellant to drive foods out of pressurized containers. It is better known as laughing gas and is safe.
Isolated fiber: Cereal, crackers, bread, muffins.
When a food ingredient contains the word "fiber," it's code for an isolated fiber. "Wheat fiber" and "oat hull fiber" are insoluble fibers, which may help prevent constipation but don't lower blood cholesterol or blood sugar. "Oat fiber" can be either insoluble or soluble fiber. Soluble fiber may lower blood cholesterol and blood sugar but doesn't prevent constipation. Finally, isolated fibers don't contain the micronutrients and phytochemicals that foods with naturally occuring fiber contain.
Fat substitute: Lay's Light Chips, Pringles Light chips.
Olestra is Procter & Gambles synthetic fat that is not absorbed as it passes through the digestive system, so it has no calories. Procter & Gamble suggests that replacing regular fat with olestra will help people lose weight and lower the risk of heart disease.
Olestra can cause diarrhea and loose stools, abdominal cramps, flatulence, and other adverse effects. Those symptoms are sometimes severe. Afflicted consumers can file reports with the Center for Science in the Public Interest.
Olestra reduces the body's ability to absorb fat-soluble carotenoids (such as alpha and beta-carotene, lycopene, lutein, and canthaxanthin) from fruits and vegetables, but an occasional serving wouldn't be a problem. Those nutrients are thought by many experts to reduce the risk of cancer and heart disease. Olestra enables manufacturers to offer greasy-feeling low-fat snacks, but consumers would be better off with baked snacks, which are safe and just as low in calories. Products made with olestra should not be called "fat free," because they contain substantial amounts of indigestible fat.
Bulking agent, emulsifier, Sweetener, prebiotic: Frozen desserts, cookies, energy and granola bars.
Oligofructose, synthesized from sucrose or extracted from chicory roots, consists of up to several dozen fructose molecules linked end to end. Like inulin and other soluble fibers, oligofructose is digested by bacteria in the large intestine, but not by human enzymes. This slightly sweet ingredient provides less than about half as many calories per gram as fructose or other sugar. Oligofructose promotes the growth of "good" bifidus bacteria.
Fat, oil, shortening: Stick margarine, crackers, fried restaurant foods, baked goods, icing, microwave popcorn.
Vegetable oil, usually a liquid, can be made into a semi-solid shortening by reacting it with hydrogen. Partial hydrogenation reduces the levels of polyunsaturated oils - and also creates trans fats, which promote heart disease. A committee of the U.S. Food and Drug Administration (FDA) concluded in 2004 that on a gram-for-gram basis, trans fat is even more harmful than saturated fat. Ideally, food manufacturers would replace hydrogenated shortening with less-harmful ingredients. The Institute of Medicine has advised consumers to consume as little trans fat as possible, ideally less than about 2 grams a day (that much might come from naturally occurring trans fat in beef and dairy products). Harvard School of Public Health researchers estimate that trans fat had been causing about 50,000 premature heart attack deaths annually, making partially hydrogenated oil one of the most harmful ingredients in the food supply (see discussion of salt below).
Beginning in 2006, Nutrition Facts labels have had to list the amount of trans fat in a serving. That spurred many companies, including Frito-Lay, Kraft, ConAgra, and others, to replace most or all of the partially hydrogenated oil in almost all their products. Usually the substitutes are healthier and the total of saturated plus trans fat is no higher than it was. Foods labeled "0g trans fat" are permitted to contain 0.5g per serving, while "no trans fat" means none at all. Consumers need to read labels carefully: foods labeled "0g trans" or "no trans" may still have large amounts of saturated fat.
Restaurants, which do not provide nutrition information, have been slower to change, but the pace of change has picked up. They use partially hydrogenated oil for frying chicken, potatoes, and fish, as well as in biscuits and other baked goods. McDonald's, Wendy's, KFC, Taco Bell, Ruby Tuesday, and Red Lobster are some of the large chains that have largely eliminated trans fat or soon will. Most large chains and many smaller independent restaurants continue to fry in partially hydrogenated oil and their French fries, fried chicken, fried fish, and pot pies contain substantial amounts of trans fat. Fortunately, the use of partially hydrogenated oil dropped by 50 percent from around 2000 to 2007.
In Denmark, the government has virtually banned partially hydrogenated oil. In 2004, the Center for Science in the Public Interest petitioned the FDA to immediately require restaurants to disclose when they use partially hydrogenated oil and to begin the process of eliminating partially hydrogenated oil from the entire food supply. While the FDA rejected the idea of requiring restaurants to disclose the presence of trans fat, New York City, Philadelphia, Boston, and other jurisdictions have set tight limits on the trans-fat content of restaurant foods. Meanwhile, the FDA is continuing to consider CSPI's petition to revoke the legal status of partially hydrogenated oil (the FDA considers that oil to be "generally recognized as safe," even though it and everyone else considers it to be "generally recognized as dangerous."
Fully hydrogenated vegetable oil does not have any trans fat, but it also does not have any polyunsaturated oils. It is sometimes mixed (physically or chemically) with polyunsaturated liquid soybean oil to create trans-free shortening. When it is chemically combined with liquid oil, the ingredient is called inter-esterified vegetable oil. Meanwhile, oil processors are trying to improve the hydrogenation process so that less trans fat forms.
Pantothenic acid is one of the water-soluble B vitamins. Human deficiencies have never been observed.
Papain is a harmless enzyme obtained from papaya that is used to break down tough muscle protein in meat.
Gelling agent: Jams, jellies.
Pectin is a safe carbohydrate that strengthens cell walls in citrus fruits, apples, beets, carrots, and other fruits and vegetables. Pectin forms gels that are the basis of fruit jellies, and may be used to thicken barbeque sauce, cranberry sauce, canned frosting, and yogurt.
Acidulant, chelating agent, buffer, emulsifier, nutrient, discoloration inhibitor: Baked goods, cheese, powdered foods, cured meat, soda pop, breakfast cereals, dehydrated potatoes.
Phosphoric acid acidifies and flavors cola beverages; the acidity erodes tooth enamel. CALCIUM and IRON PHOSPHATES act as mineral supplements. SODIUM ALUMINUM PHOSPHATE is a leavening agent. CALCIUM and AMMONIUM PHOSPHATES serve as food for yeast in baking. SODIUM ACID PYROPHOSPHATE prevents discoloration in potatoes and sugar syrups. SODIUM PHOSPHATES helps retain moisture in processed meats and prevent harmless mineral (struvite) glass-like crystals from forming in canned tuna.
While excessive consumption of phosphates could lead to dietary imbalances that might contribute to osteoporosis, only a small fraction of the phosphate in the American diet comes from additives. Most comes from meat and dairy products.
Cholesterol-lowering additive: Margarine, fruit juice, bread, dietary supplements.
These substances are minor components of membranes in many nuts, seeds, vegetable oils, fruits, vegetables and other foods. They are chemically related to cholesterol. They are more easily incorporated into foods (other than fruit juices) when they are converted to ester forms. Then, when consumed in high doses from foods or dietary supplements, the sterol or stanol esters reduce the absorption of cholesterol from food and can lower LDL (“bad”) blood cholesterol levels by 10 to 15 percent. They are not toxic, but they may reduce the body's absorption of nutrients called carotenoids that are thought to reduce the risk of cancer and heart disease.
Bulking agent: Reduced-calorie salad dressings, baked goods, candies, puddings, frozen desserts.
Polydextrose is made by combining dextrose (corn sugar) with sorbitol. The result is a slightly sweet, reduced-calorie (only one calorie per gram because it is poorly digested) bulking agent. The FDA requires that if a serving of a food would likely provide more than 15 grams of polydextrose, the label should advise consumers that "Sensitive individuals may experience a laxative effect from excessive consumption of this product."
Emulsifier: Chocolate candy, margarine.
PGPR is one of those mysterious chemicals that manufacturers use in food production. It stabilizes low-fat, high-water margarines and helps the "flow properties" in candy production. Despite its long chemical name, PGPR is safe.
Emulsifier: Baked goods, frozen desserts, imitation cream.
Polysorbate 60 is short for polyoxyethylene-(20)- sorbitan monostearate. It and its close relatives, POLYSORBATE 65 and 80, work the same way as mono- and diglycerides, but smaller amounts are needed. They keep baked goods from going stale, keep dill oil dissolved in bottled dill pickles, help coffee whiteners dissolve in coffee, and prevent oil from separating out of artificial whipped cream.
Flour improver: White flour, bread and rolls.
This additive has long been used to increase the volume of bread and to produce bread with a fine crumb (the not-crust part of bread) structure. Most bromate rapidly breaks down to form innocuous bromide. However, bromate itself causes cancer in animals. The tiny amounts of bromate that may remain in bread pose a small risk to consumers. Bromate has been banned virtually worldwide except in Japan and the United States. It is rarely used in California because a cancer warning might be required on the label. In 1999, the Center for Science in the Public Interest petitioned the FDA to ban bromate. Since then, numerous millers and bakers have stopped using bromate.
Potassium chloride is used in some salt substitutes as a way to reduce sodium, a major cause of high blood pressure and heart disease and strokes. No-Salt salt substitute consists entirely of potassium chloride, while Morton's Lite Salt is half potassium chloride and half sodium chloride. The amount of potassium chloride used in foods is almost self-limiting, because most people perceive potassium chloride to taste extremely bitter. This additive is safe, but people with kidney disease and certain heart conditions need to talk to their doctors about avoiding large amounts.
Antioxidant preservative: Vegetable oil, meat products, potato sticks, chicken soup base, chewing gum.
Propyl gallate retards the spoilage of fats and oils and is often used with BHA and BHT, because of the synergistic effects those preservatives have with one another. The best studies on rats and mice suggested that this preservative might cause cancer. This additive needs to be better studied.
Nutrient: Breakfast cereals, instant breakfasts, health-food bars.
Pyridoxine, or vitamin B6, serves a variety of functions in the body and performs a central role in amino acid metabolism. Wheat germ, brown rice, and yeast are rich sources of pyridoxine. It is safe.
Flavoring: Tonic water, quinine water, bitter lemon.
This drug can cure malaria and is used as a bitter flavoring in a few soft drinks. There is a slight chance that quinine causes birth defects, so, to be on the safe side, pregnant women should avoid quinine-containing beverages and drugs. Relatively poorly tested.
Natural, high-potency sweetener: Used in diet beverages. Also called rebaudioside A; sold under brand names Truvia and PureVia. Purified from crude extracts of stevia, which itself is sold as a table-top sweetener at some "health food" stores.
Stevia, which is about 100 times sweeter than sugar, is obtained from a shrub (yerba dulce) that traditionally grew in Brazil and Paraguay, but now also in southeast Asia and elsewhere. The actual sweet chemicals are the closely related stevioside and rebaudioside A.
Many consumers and the food industry have high hopes for stevia and its derivatives, because these non-caloric sweeteners are naturally derived alternatives to the controversial synthetic sweeteners (SACCHARIN, ASPARTAME, ACESULFAME-K, SUCRALOSE, CYCLAMATE). Stevia has long been used in Japan and several other countries. Still, some, but certainly not all, people perceive stevia and its sweet derivatives to have an unpleasant aftertaste, which companies are trying feverishly to overcome.
In the 1990s, the U.S. Food and Drug Administration (and Canada and the European Union) rejected stevia for use as a food ingredient. High dosages fed to rats reduced sperm production and increased cell proliferation in their testicles, which, at least at those dosages, could cause infertility or other problems. Pregnant hamsters that had been fed large amounts of a derivative of stevioside called steviol had fewer and smaller offspring. In the laboratory, steviol can be converted into a mutagenic compound, which may promote cancer by causing mutations in the cells' DNA.
In the early 21st century, Cargill and Merisant (marketer of aspartame-based Equal) developed extracts of stevia that are 95 percent pure rebaudioside A and 200 times as sweet as sugar. The companies call their products Truvia and PureVia, respectively, with the nickname of rebiana. In 2008, Cargill and Merisant (and other smaller companies) told the FDA that rebiana should be considered "generally recognized as safe," or GRAS. (GRAS substances are given less scrutiny by the FDA than standard food additives.)
The one nagging concern about rebiana is that several (but not all) genetic tests found that rebiana-related substances caused mutations and other problems. That should have spurred the FDA to require additional animal feeding studies. Rebaudioside A has only been subjected to chronic feeding studies in rats, but not mice (testing guidelines generally call for those tests in two rodent species). Nevertheless, in late 2008 the FDA accepted the chemical as GRAS. Companies quickly started marketing a wide range of lower-calorie, rebiana-sweetened products, with the sweetener replacing some or all of the sugar.
Some food and beverage companies are trying to mask the aftertaste of rebiana with various ingredients, including ERYTHRITOL or modest amounts of sugar. Meanwhile, companies are developing other natural sweeteners, such as MOGROSIDES (monk fruit extract), MONATIN, and others. Ultimately, those substances, or mixtures of them, might play an important role in reducing the harm caused by SUGAR and HIGH-FRUCTOSE CORN SYRUP.
Nutrient: Enriched flour, breakfast cereals, and other vitamin-fortified foods.
Riboflavin is simply vitamin B2. Riboflavin plays a crucial role in activating numerous enzymes. It is safe.
Artificial sweetener: Diet, no-sugar-added products, soft drinks, sweetener packets.
Saccharin (Sweet N Low) is 350 times sweeter than sugar and is used in diet foods or as a tabletop sugar substitute. Many studies on animals have shown that saccharin can cause cancer of the urinary bladder. In other rodent studies, saccharin has caused cancer of the uterus, ovaries, skin, blood vessels, and other organs. Other studies have shown that saccharin increases the potency of other cancer-causing chemicals. And the best epidemiology study (done by the National Cancer Institute) found that the use of artificial sweeteners (saccharin and cyclamate) was associated with a higher incidence of bladder cancer.
In 1977, the FDA proposed that saccharin be banned, because of studies that it causes cancer in animals. However, Congress intervened and permitted it to be used, provided that foods bear a warning notice. It has been replaced in many products by aspartame (NutraSweet). In 1997, the diet-food industry began pressuring the U.S. and Canadian governments and the World Health Organization to take saccharin off their lists of cancer-causing chemicals. The industry acknowledges that saccharin causes bladder cancer in male rats, but argues that those tumors are caused by a mechanism that would not occur in humans. Many public health experts respond by stating that, even if that still-unproved mechanism were correct in male rats, saccharin could cause cancer by additional mechanisms and that, in some studies, saccharin has caused bladder cancer in mice and in female rats and other cancers in both rats and mice.
In May 2000, the U.S. Department of Health and Human Services removed saccharin from its list of cancer-causing chemicals. Later that year, Congress passed a law removing the warning notice that likely will result in increased use in soft drinks and other foods and in a slightly greater incidence of cancer.
Modified fat: Baked goods, candy.
This manufactured fat (developed by Nabisco) has the physical properties of regular fat, but the manufacturer claims it provides only about 5/9 as many calories. Its use can enable companies to make reduced-calorie claims on their products. Salatrim's low calorie content results from its content of stearic acid, which the manufacturer says is absorbed poorly, and short-chain fatty acids, which provide fewer calories per unit weight.
Critics have charged that it does not provide as big a calorie reduction as claimed by Nabisco. Moreover, only very limited testing has been done to determine effects on humans. Eating small amounts of salatrim is probably safe, but large amounts (30g or more per day) increase the risk of such side effects as stomach cramps and nausea. No tests have been done to determine if the various food additives (salatrim, olestra, mannitol, and sorbitol) that cause gastrointestinal symptoms can act in concert to cause greater effects.
Nabisco declared salatrim safe and has marketed it, as the law allows, without formal FDA approval. (Nabisco has since sold salatrim to another company, Cultor.) In June 1998, the Center for Science in the Public Interest urged the FDA to ban salatrim until better tests were done and demonstrated safety. The FDA rejected that recommendation, but salatrim is not widely used, if at all.
Flavoring, preservative: Most processed foods, cured meats, soup, snack chips, crackers, and others.
Salt, at the levels present in the diets of most people around the world, is probably the single most harmful substance in the food supply. Salt is used liberally in many processed foods and restaurant meals, with some meals containing far more than a day's worth of sodium. Other additives, such as monosodium glutamate and sodium benzoate, contribute additional sodium. Salt serves many purposes in foods, such as acting as a preservative, adding a salty flavor, masking bitter flavors, and fostering expected texture or other property.
A diet high in sodium increases blood pressure in most people, thereby increasing the risk of heart attack and stroke. In 2004, the director of the U.S. National Heart, Lung, and Blood Institute and two colleagues estimated that cutting the amount of sodium in packaged and restaurant foods by half would save 150,000 lives a year. Everyone should avoid salty processed foods and restaurant meals, use salt sparingly in cooking and at the table, and enjoy other seasonings.
The Food and Drug Administration considers salt to be "generally recognized as safe" (GRAS), even though it recognizes that diets high in salt are a major cause of cardiovascular disease and even though its own advisory committee in 1979 concluded that salt should not be considered GRAS. In 1978 and 2005 the Center for Science in the Public Interest petitioned the FDA to revoke salt's GRAS status and take other steps to lower sodium levels in the food supply. In response, the FDA held a public hearing in November, 2007. Meanwhile, the British government has made salt reduction one of its top health goals and has been having significant success.
Many companies defend the amounts of salt used, saying that using less would sacrifice taste or safety. However, comparisons of different brands of the same product frequently show wide differences in sodium content. That indicates that many companies could use less salt (or other sodium-containing ingredients) to the levels used by competitors and still have perfectly marketable products.
Anti-caking agent: salt, soups, coffee creamer, and other dry, powdery foods.
This chemical is just sand. Silicon dioxide occurs naturally in foods, especially foods derived from plants. Breathed in, silica dust can cause lung disease, even cancer. For use in food, it is finely ground and added to salt and other foods to help powders flow more easily. Aluminium calcium silicate and tricalcium silicate are also used in foods, and calcium silicate is used in some dietary supplements.
Preservative: Fruit juice, carbonated drinks, pickles.
Manufacturers have used sodium benzoate (and its close relative benzoic acid) for a century to prevent the growth of microorganisms in acidic foods. The substances occur naturally in many plants and animals. They appear to be safe for most people, though they cause hives, asthma, or other allergic reactions in sensitive individuals.
Another problem occurs when sodium benzoate is used in beverages that also contain ascorbic acid (vitamin C). The two substances, in an acidic solution, can react together to form small amounts of benzene, a chemical that causes leukemia and other cancers. Though the amounts of benzene that form are small, leading to only a very small risk of cancer, there is no need for consumers to experience any risk. In the early 1990s the FDA had urged companies not to use benzoate in products that also contain ascorbic acid, but in the 2000s companies were still using that combination. A lawsuit filed in 2006 by private attorneys ultimately forced Coca-Cola, PepsiCo, and other soft-drink makers in the U.S. to reformulate affected beverages, typically fruit-flavored products.
Thickening and stabilizing agent, Prevents sugar from crystallizing: Ice cream, beer, pie fillings, icings, diet foods, candy.
CMC is made by reacting cellulose with a derivative of acetic acid. Studies indicate it is safe.
Antioxidant, color retainer: Processed meat, beverages, baked goods, and potato salad.
Chemically, sodium erythorbate is stereoisomer of ascorbic acid (vitamin C), but it itself has no nutritional value. It is used most commonly in processed meats, where it retards nitrosamine formation and color fading.
Preservative, coloring, flavoring: Bacon, ham, frankfurters, luncheon meats, smoked fish, corned beef.
Meat processors love sodium nitrite because it stabilizes the red color in cured meat (without nitrite, hot dogs and bacon would look gray) and gives a characteristic flavor. Sodium nitrate is used in dry cured meat, because it slowly breaks down into nitrite. Adding nitrite to food can lead to the formation of small amounts of potent cancer-causing chemicals (nitrosamines), particularly in fried bacon. Nitrite, which also occurs in saliva and forms from nitrate in several vegetables, can undergo the same chemical reaction in the stomach. Companies now add ascorbic acid or erythorbic acid to bacon to inhibit nitrosamine formation, a measure that has greatly reduced the problem. While nitrite and nitrate cause only a small risk, they are still worth avoiding.
Several studies have linked consumption of cured meat and nitrite by children, pregnant women, and adults with various types of cancer. Although those studies have not yet proven that eating nitrite in bacon, sausage, and ham causes cancer in humans, pregnant women would be prudent to avoid those products.
The meat industry justifies its use of nitrite and nitrate by claiming that it prevents the growth of bacteria that cause botulism poisoning. Thats true, but freezing and refrigeration could also do that, and the U.S. Department of Agriculture has developed a safe method using lactic-acid-producing bacteria. The use of nitrite and nitrate has decreased greatly over the decades, because of refrigeration and restrictions on the amounts used. The meat industry could do the publics health a favor by cutting back even further. Because nitrite is used primarily in fatty, salty foods, consumers have important nutritional reasons for avoiding nitrite-preserved foods.
The labels on some "natural" hot dogs and other cured meats brag about "no added nitrite." Be skeptical. While those products may not contain added sodium nitrite, they sometimes are made with celery powder or celery juice which are naturally high in nitrite. Indeed in 2011 the New York Times revealed that the "natural" cured meats could have 10 times as much nitrite as conventional products. The bottom line: those products typically are high in salt and sometimes saturated fat, so they'd be worth eating only occasionally or avoiding entirely.
Prevents growth of mold: Cheese, syrup, jelly, cake, wine, dry fruits.
Sorbic acid occurs naturally in many plants. These additives are safe.
Emulsifier: Cakes, candy, frozen pudding, icing.
Like mono- and diglycerides and polysorbates, this additive keeps oil and water mixed together. In chocolate candy, it prevents the discoloration that normally occurs when the candy is warmed up and then cooled down.
Sweetener, thickening agent, maintains moisture: Dietetic drinks and foods, candy, shredded coconut, chewing gum.
Sorbitol occurs naturally in fruits and berries and is a close relative of sugars. It is half as sweet as sugar. It is used many dietetic foods. It is used in non-cariogenic (non-decay-causing) chewing gum because oral bacteria do not metabolize it well. Some diabetics use sorbitol-sweetened foods because it is absorbed slowly and does not cause blood sugar to increase rapidly. Moderate amounts of sorbitol are safe, but large amounts may have a strong laxative effect and even cause diarrhea. The FDA requires foods "whose reasonably foreseeable consumption may result in a daily ingestion of 50 grams of sorbitol" to bear the label statement: "Excess consumption may have a laxative effect."
Thickening agent: Soup, gravy, frozen foods.
Starch, the major component of flour, potatoes, and corn, is used in many foods as a thickening agent. However, starch does not dissolve in cold water. Chemists have solved this problem by reacting starch with various chemicals to create MODIFIED STARCHES (see next entry).
Starch made from breeds of high-amylose corn is relatively resistant to digestion. That "resistant starch" has some of the same benefits of naturally occurring dietary fiber.
Starch is made up of two large carbohydrate molecules. Amylose is insoluble carbohydrate made up of long chains of glucose molecules. Amylopectin is a large, water-soluble, branched-chain polysaccharide that constitutes the other part of starch.
Thickening agent: Soup, gravy, frozen foods.
Modified starches are used in processed foods to improve their consistency and keep the solids suspended. Starch and modified starches used to be used in baby foods to replace large percentages of more nutritious ingredients, such as fruit.
Antioxidant, chewing gum base, Flavoring, anti-caking agent (calcium stearate).
Stearic acid is a fatty acid that occurs in virtually all fats. Though it is a saturated fat, it does not appear to affect blood cholesterol levels. However, it might increase the risk of heart disease by raising fibrinogen levels and causing blood clots. The trivial amounts used as an additive are harmless.
Artificial sweetener: No-sugar-added baked goods, frozen desserts, ice cream, soft drinks, tabletop sweetener (Splenda).
Approved in the United States in 1998, sucralose — marketed as Splenda — is used in soft drinks, baked goods, ice cream, sweetener packets, and other products. It previously had been used in Canada, Europe, and elsewhere. Sucralose is safer than saccharin, acesulfame-K, and cyclamate, but it is often used in conbination with acesulfame-K. Unlike aspartame, sucralose can be used in baked goods.
When sucralose was first being considered for approval by the FDA, the Center for Science in the Public Interest objected. A study in rats had indicated that the additive might cause premature shrinkage of the thymus gland, which is part of the immune system. However, a subsequent study did not find any problem. Likewise, studies designed to detect whether sucralose could cause cancer in lab animals did not find any problems.
A 2002 study in mice found that huge doses of sucralose caused DNA damage in mice, but numerous other genetic studies did not find any problems. More recently, a 2008 study funded by the sugar industry purported to show that large amounts of Splenda upset the balance of bacteria and had other effects in the gastrointestinal tract of rats. Unfortunately, the study was poorly designed; it should be repeated with an improved design before demonstrating a problem.
In 2012, an independent Italian laboratory announced (but has not yet published) a study that was said to find that sucralose caused leukemia in mice. That was the same lab that several years earlier published studies indicating that aspartame caused leukemia in rats. Because of possible flaws in the aspartame studies, the findings on both artificial sweeteners need to be confirmed by other independent scientists before one could conclude that either poses a real risk to consumers.
The manufacturer, McNeil Nutritionals, long advertised Splenda as being "made from sugar, so it tastes like sugar." That statement may be literally true, but is misleading, as the Sugar Association charged in a lawsuit. In fact, the sweetener is a synthetic chemical made by chemically reacting sugar (sucrose) with chlorine. However, the fact that sucralose is synthetic does not make it unsafe. Also, be aware that artificial sweeteners are being used more and more often without any disclosure on front labels. Read ingredient lists carefully if you are concerned about any of those sweeteners.
Sweetener: Table sugar, sweetened foods.
Sucrose, ordinary table sugar, occurs naturally in fruit, sugar cane, and sugar beets. Industry produced 64 pounds of sugar per person in 2009. That figure is down from 119 pounds per year around 1970, but the decrease has been more than made up for by increased use of high-fructose corn syrup and dextrose. In 2009, industry produced a total of about 131 pounds of refined sugars per person, though because of waste and spoilage the average American actually consumed about 93 pounds of all refined sugars (almost two pounds per week). That represents a 14-percent reduction from the 1999 high of 108 pounds. That historic decline resulted largely from declining soft drink consumption (due partly to increased health concerns and to the popularity of bottled water).
Sugar and sweetened foods may taste good and supply energy, but most people eat too much of them. Sugar, corn syrup, and other refined sweeteners make up 16 percent of the average diet, but provide no vitamins, minerals, or protein. That means a person would have to get 100 percent of his or her nutrients from only 84 percent of his or her food. And, of course, some people, especially teen-aged boys, consume as much as 25 percent of their calories from refined sugars.
When sugar is digested, it breaks down into one fructose and one glucose molecule. Small amounts of fructose and glucose from fruits, vegetables, sugar, HFCS, or other sources are safe. However, large amounts promote tooth decay and displace nutrient-rich foods with empty calories. Furthermore, large amounts of glucose boost blood sugar levels and large amounts of fructose increase triglyceride (fat) levels and small, dense LDL ("bad") cholesterol levels in blood, and may thereby increase the risk of heart disease. Also, recent studies show that consuming 25 percent of calories from fructose or HFCS (which is about half fructose) leads to more visceral (deep belly) fat or liver fat. Those changes may increase the risk of diabetes and heart disease. Finally, preliminary research suggests that large amounts of fructose may upset levels of such hormones as leptin and ghrelin, which regulate appetite, thereby contributing to weight gain and obesity.
The Dietary Guidelines for Americans (America's basic nutrition policy), American Heart Association, and other health authorities recommend that people consume no more than about 3 to 8 percent of calories in the form of refined sugars. That's far less than the current average of 16 percent of calories. The bottom line: the less added sugars—fructose, sucrose, or HFCS—one consumes the better (though, again, small amounts are safe).
Some companies have been replacing high-fructose corn syrup with sugar, pretending that that makes their products more healthful. In fact, there's essentially no nutritional difference between sugar and high-fructose corn syrup, so just ignore the marketing hype.
Preservative, bleach: Dried fruit, wine, processed potatoes.
Sulfiting agents prevent discoloration (dried fruit, some "fresh" shrimp, and some dried, fried, or frozen potatoes) and bacterial growth (wine). They also destroy vitamin B-1 and, most important, can cause severe reactions, especially in asthmatics. To non-sensitive individuals, sulfites are safe. If you think you may be sensitive, avoid all forms of this additive, because it caused at least twelve identifiable deaths in the 1980s and probably many, many more in the preceding decades. Deaths and less severe reactions were linked most commonly to restaurants foods. Sulfite levels in the lettuce and potatoes served at restaurants were often extremely high, because workers would allow the vegetable to sit in a sulfite solution for far too long a time. As a result of pressure from the Center for Science in the Public Interest (CSPI), a congressional hearing, and media attention, the FDA banned the most dangerous uses of sulfites and required that wine labels list sulfite, when used. Since those actions, CSPI has not been aware of any additional deaths.
This new synthetic additive is chemically related to fructose, but is poorly absorbed by the body. That's why it yields only about one-third as many calories and why large amounts cause diarrhea, nausea, and flatulence. In one study, 20 grams (about five teaspoons) caused nausea. Tagatose does not promote tooth decay.
Antioxidant: Beverages, candy, ice cream, baked goods, yogurt, gelatin desserts, baking powder.
Tartaric acid occurs naturally in grapes, other fruits, and coffee beans. It has an extremely tart, acidic taste, which is useful in some foods. Most of the tartaric acid we ingest is digested by bacteria in the intestines. The 20 percent that is absorbed is rapidly excreted in the urine.
When tartaric acid is partially neutralized with potassium hydroxide, the result is potassium acid tartrate, or cream of tartar.
Pretend benefits: Energy drinks.
Taurine occurs naturally in shellfish, other seafood, and meat. Companies add large amounts to energy drinks because it's supposedly energizing, but no credible evidence exists for that claim. There are no reports of harm from the taurine added to drinks.
Antioxidant: vegetable oil, snack foods, cereals, other fat-containing foods.
This preservative prevents rancidity. It is sometimes used along with similar preservatives, including BHA, BHT, and propyl gallate, with which it has a synergistic effect. (TBHQ is chemically related to BHA and forms when BHA is metabolized by the body.) One benefit of TBHQ over those other preservatives is that it does not cause discoloration in the presence of iron.
In long-term feeding studies conducted by the U.S. National Toxicology Program, high doses of TBHQ actually reduced rates of mammary tumors in rats. No problems were seen in mice.
Natural high-intensity sweetener: wide variety of foods and beverages.
This sweetener consists of a couple of proteins extracted from the katemfe fruit grown in west Africa. It is about 2,000 times sweeter than sugar (sucrose). Like rebiana and mogrosides, other natural, high-potency sweeteners, it is said to have a "licorice-like" aftertaste, which consumers may find distasteful and which just might be the reason it is rarely used. As a protein it is presumably safe (the FDA accepts it as GRAS), but might cause occasional allergic reactions.
Perfectly safe, despite adding minuscule amounts of nitrate to our food.
Wetting agent: Beverages.
This perfectly safe chemical is used in small amounts in foods and drinks to reduce the surface tension of water.
Enzyme to bind proteins: Beef, poultry dairy, seafood, and other protein-rich products.
You'll never see this ingredient listed on food labels, because it appears to be used primarily by restaurant chefs. Transglutaminase's marketer (Ajinomoto) calls it "a revolutionary new way to improve existing food products or allow 'out of the box' thinking in making new food products." What it does is enable a chef to "glue" together a bunch of scraps of meat and sell it as a steak, bind bacon to meat, improve the texture of cheese, and do other tricks. Transglutaminase is a naturally occurring enzyme that is presumably safe, but used to deceive consumers. Also, because binding two pieces of food together puts into the protected center of meat or seafood any bacteria that were on the outside of a piece and, hence, easily killed in cooking. It is for that reason that we consider this ingredient, which on its own is safe, as a potential safety risk.
Substitute for vanilla: Ice cream, baked goods, beverages, chocolate, candy, gelatin desserts.
Vanilla flavoring is derived from a bean, but vanillin, the major flavor component of vanilla, is cheaper to produce in a factory. A derivative, ethyl vanillin, comes closer to matching the taste of real vanilla. Both chemicals are safe.
Nutrient: Fortified milk.
Vitamin D is an essential nutrient that is produced by sunlight in the skin and that occurs naturally in such animal foods as fatty fish, eggs, butter, and liver. Recent research indicates, but has not yet proven, that the great majority of people are not getting enough vitamin D from sunlight or consuming enough in the form of foods or dietary supplements (look for vitamin D3). Increasing our consumption of vitamin D might reduce the risks of colon cancer, high blood pressure, and heart disease. Though the official recommended intake of D is 400 IU per day, it would be worth shooting for closer to 1,000. (Talk to your doctor about any special concerns related to your specific health situation.)
The food and chemical industries have said for decades that all food additives are well tested and safe. And most additives are safe. However, the history of food additives is riddled with additives that, after many years of use, were found to pose health risks. Those listed below have been banned. The moral of the story is that when someone says that all food additives are well tested and safe you should take their assurances with a grain of salt.
|Additive||Function||Natural or Synthetic||Year Banned||Problem|
|Agene (nitrogen trichloride)||flour bleaching and aging agent||synthetic||1949||Dogs that ate bread made from treated flour suffered epileptic-like fits; the toxic agent was methionine sulfoxime.|
|artificial coloring||synthetic||1919||Toxic, later found to cause liver cancer.|
|artificial coloring||synthetic||1965||Liver cancer|
|artificial coloring||synthetic||1965||Insufficient economic importance to be tested|
|artificial coloring||synthetic||1956||Organ damage|
|artificial coloring||synthetic||1960||Organ damage|
|artificial coloring||synthetic||1978 (ban never finalized)||Contained low levels of a cancer-causing contaminant. Orange B was used only in sausage casings to color sausages, but is no longer used in the United States.|
|artificial coloring||synthetic||1961||Liver cancer|
|artificial coloring||synthetic||1976||Possible carcinogen|
|artificial coloring||synthetic||1976||High levels damaged adrenal cortex of dog; after 1965 it was used only in maraschino cherries and certain pills; it is still allowed in externally applied drugs and cosmetics.|
|artificial coloring||synthetic||1956||Damages internal organs and may be a weak carcinogen; since 1956 it continues to be used under the name Citrus Red 2 only to color oranges (2 ppm).|
|artificial coloring||synthetic||1919||Toxic, later found to be carcinogenic.|
|artificial coloring||synthetic||1973||Cancer (it had been used to stamp the Department of Agricultures inspection mark on beef carcasses).|
|artificial coloring||synthetic||1959||Intestinal lesions at high dosages.|
|artificial coloring||synthetic||1959||Heart damage at high dosages.|
|artificial coloring||synthetic||1959||Heart damage at high dosages.|
|cinnamyl anthranilate||artificial coloring||synthetic||1982||Liver cancer|
|cobalt salts||stabilize beer foam||synthetic||1966||Toxic effects on heart|
|coumarin||flavoring||tonka bean||1970||Liver poison|
|cyclamate||artificial sweetener||synthetic||1969||Bladder cancer, damage to testes; now not thought to cause cancer directly, but to increase the potency of other carcinogens.|
|diethyl pyrocarbonate (DEPC)||preservative (beverages)||synthetic||1972||Combines with ammonia to form urethane, a carcinogen|
|dulcin (p-ethoxy-phenylurea)||artificial sweetener||synthetic||1950||Liver cancer|
|ethylene glycol||solvent||synthetic||1998||Kidney damage|
|monochloroacetic acid||preservative||synthetic||1941||Highly toxic|
|nordihydroguaiaretic acid (NDGA)||antioxidant||desert plant||1968 (FDA), 1971 (USDA)||Kidney damage|
|oil of calamus||flavoring||root of calamus||1968||Intestinal cancer|
|polyoxyethylene-8-stearate (Myrj 45)||emulsifier||synthetic||1952||High levels caused bladder stones and tumors|
|safrole||flavoring (root beer)||sassafras||1960||Liver cancer|
|thiourea||preservative||synthetic||c. 1950||Liver cancer|
is used to make foods more acidic for reasons of taste, preservation, or other purpose.
retard the oxidation of unsaturated fats and oils, colorings, and flavorings. Oxidation leads to rancidity, flavor changes, and loss of color. Most of those effects are caused by reaction of oxygen in the air with fats.
is a chemical or other agent that causes cancer in animals or humans.
trap trace amounts of metal atoms that would otherwise cause food to discolor or go rancid.
keep oil and water mixed together.
have little or no flavor of their own, but accentuate the natural flavor of foods. They are often used when very little of a natural ingredient is present.
are natural or chemically modified carbohydrates that absorb some of the water that is present in food, thereby making the food thicker. Thickening agents "stabilize" factory-made foods by keeping the complex mixtures of oils, water, acids, and solids well mixed.
Chemicals usually are tested for an ability to cause cancer by feeding large dosages to small numbers of rats and mice. Large dosages are used to compensate for the small number of animals that can be used (a few hundred is considered a big study, though it is tiny compared to the U.S. population of more than 300 million). Also, the large dosages can compensate for the possibility that rodents may be less sensitive than people to a particular chemical (as happened with thalidomide). Some people claim that such tests are improper and that large amounts of any chemical would cause cancer. That is not true. Huge amounts of most chemicals do not cause cancer. When a large dosage causes cancer, most scientists believe that a smaller amount would also cause cancer, but less frequently.
It would be nice if lower, more realistic dosages could be used, but a test using low dosages and a small number of animals would be extraordinarily insensitive. It would also be nice if test-tube tests not using any animals were developed that could cheaply and accurately identify cancer-causing chemicals. While some progress has been made in that direction, those tests have not proven reliable. Thus, the standard high-dosage cancer test on small numbers of animals is currently the only practical, reasonably reliable way to identify food additives (and other chemicals) that might cause cancer.
The Delaney Clause is an important part of the federal Food, Drug, and Cosmetic Act. That important consumer-protection clause specifically bans any additive that "is found to induce cancer when ingested by man or animal." The food and chemical industries are seeking to weaken or repeal that law.