St. John's Wort and Kava
by David Schardt
St. Johns Wort|
St. Johns wort blooms in June, around the traditional date of the saints birth. Hence its name (wort is an old Anglo-Saxon term for plant).
But the herb didnt really blossom until the mid-1990s, when it catapulted from an obscure folk treatment for wounds and melancholy to a trendy street-legal antidepressant...and the hottest supplement since ginkgo.
The trigger? A 1996 meta-analysis in the prestigious British Medical Journal that pooled the results of more than a dozen European studies on St. Johns wort in people suffering mild to moderate clinical depression.1
Clinical depression is more than just feeling depressed or down. Among the symptoms, which can persist for months or years: feelings of worthlessness and hopelessness; loss of interest in activities that were once enjoyed; sleep disturbances; thoughts of suicide; difficulty concentrating or remembering; loss of appetite or overeating; and persistent physical symptoms like headaches, digestive disorders, and chronic pain that dont respond to treatment.
Most of the pooled studies in the meta-analysis tracked their participants state of mind using the Hamilton Depression Scale (HDS), which measures day-to-day symptoms of depression like guilt, suicidal thoughts, irregular sleep, and weight changes. Its the same gauge thats typically used to test new prescription drugs for depression.
The meta-analysis made headlines: The 408 people taking St. Johns wort were nearly three times as likely to show improvement as the 420 people taking a (lookalike but wort-free) placebo.
The studies in the meta-analysis were reasonably well done, says Jacques Bradwejn, Chief of Psychiatry at the Royal Ottawa Hospital in Canada. But theyre not comparable in quality to the kinds of studies necessary to have a new antidepressant drug approved. Some unanswered questions:
How long? The studies lasted only an average of five weeks. The longest was two months. Many people suffer from chronic depression and need to take medication for months and years, says Bradwejn. The studies done so far dont show for how long St. Johns wort works or for how long people need to take it.
How many helped? About half the people on St. Johns wort did better than those on the placebo. But that means about half didnt.
How depressed? None of the studies looked at whether St. Johns wort helped people with severe depression or people with clinical depression plus clinical anxiety.
How much? In some of the studies, the volunteers were given five times more St. Johns wort than in others. The meta-analysis didnt try to figure out how much of which brands worked...or didnt work.
|THE BOTTOM LINE|
St. Johns wort appears to help about half of those with mild to moderate depression. No good research has looked at whether its useful in treating severe depression or whether it can "chase the blues away" or "smooth out lifes little ups and downs."
There are no studies on the long-term safety of taking St. Johns wort. Short-term side effects seem to be mild, though it can cause an inflammation of the skin. "While this seldom happens with normal doses," says botanicals expert Varro Tyler, "those who take the herb for extended periods should be aware of the possibility and discontinue usage if it occurs."
Researchers have little information about St. Johns worts possible interactions with other drugs.
Three additional studies in the meta-analysis pitted St. Johns wort against prescription antidepressants for four to six weeks. Sixty-four percent of the herb-takers improved, compared to 58 percent of the drug-takers. Statistically, thats a tie.
These studies only used low doses of the older tricyclic antidepressants like Toframil, not the new generation of selective serotonin reuptake inhibitors like Prozac or Zoloft, points out Bradwejn. So we dont know how well St. Johns wort compares with them.
Even so, the humble herb looks pretty impressive. And it looks even better when you consider that volunteers who took St. Johns wort reported no more side effects than people who got the placebos. Whats more, they were less than half as likely to report side effects as those who took the antidepressant drugs.
Some St. Johns wort-takers complained of dizziness, gastrointestinal upset, increased sensitivity to sunlight, fatigue, and confusion. But these problems were usually mild, says Jerry Cott, chief of the Adult Psychopharmacology Research Program at the National Institute of Mental Health in Rockville, Maryland.
So why not take St. Johns wort on your own if you think youre depressed?
Long-term safety is always a question with herbs, of course. Traditionally, St. Johns wort was not used every day for long periods of time. more, relying on St. Johns wort alone could delay you from getting the help you really need.
People can self-diagnose their problems incorrectly and not realize that they suffer from something that would benefit from other kinds of therapy rather than from a pill, says Bradwejn. Plus, they dont always remember how well they should feel and when to stop taking medication or when to keep taking it.
People who suffer from depression frequently become isolated from others, says Soo Borson, director of Geropsychiatry Services at the University Of Washington Medical Center in Seattle. Effective treatment includes help in reconnecting with others. Going into the cupboard for St. Johns wort to treat ones depression by oneself may be counterproductive.
Bradwejns advice: Someone whose depression is not too intense might try St. Johns wort with the aid of a psychologist or psychiatrist. Like prescription antidepressants, it takes a minimum of four weeks to kick in, so set a goal of eight weeks for the relief of symptoms. If it hasnt worked by then, try something else.
Beating the Blues
Try to find the depression on any bottle or advertisement for St. Johns wort. Why it there? A dietary supplement company that uses the d word risks getting its product confiscated by the Food and Drug Administration (FDA) for even suggesting that it can prevent or treat a disease.
Thats why all youll see are vague invitations to try St. Johns wort if you want to beat the blues (Prosol Plus), if you feel like life has let you down (HyperiCalm), or if you need something to help maintain emotional balance and well-being (Kira).
While those claims are legal (dont call us; its Congresss fault), theyre not based on any scientific studies. No ones ever looked to see if St. Johns wort can help people who arent suffering from clinical depression shake the blues or get back on track.
Down the Pipe
This fall, St. Johns wort will be the subject of the first major federally funded study of an herbal supplement.
The trial, which is being sponsored by the National Institute of Mental Health, will pit the Kira brand against both a placebo and a popular antidepressant for eight weeks in 336 patients suffering from moderate to severe depression. People who respond to St. Johns wort will be followed up for an additional four months. Kira is the brand most often used in the successful European studies. Its made by Lichtwer Pharma, which also makes the popular Kwai brand garlic supplement.
This new trial will bring the study of St. Johns wort up to standard and put it on more solid scientific ground, says Bradwejn, who helped design the study. And it will develop a better profile of possible side effects.
1. British Medical Journal 313: 253, 1996.
On special occasions, people living in the South Pacific serve a mood-altering beverage brewed from the ground-up roots of the kava kava tree, just as theyve done for thousands of years.
Its ritual use as a mild sedative to produce a state of well-being has been described by numerous anthropologists, including Margaret Mead, says Mark Blumenthal of the American Botanical Council in Austin, Texas.
Save your airfare. This years herbal superstar (The Wall Street Journal) is as close as your local supermarket or health food store. Who can resist an invitation like the one from Kavatrol, the most widely advertised brand: Move to another state...a calmer state?
Can kava help bring relief from the stresses and annoyances of daily life? Only one bit of research suggests that it might: an unpublished study released on the World Wide Web (by the makers of Kavatrol).
Five published studies, all conducted in Europe, have compared kava with (lookalike but kava-free) placebos in several hundred people with mild to moderate clinical anxiety.1-5 Thats far more than occasionally feeling nervous or tense. According to the National Institute of Mental Health, an anxiety disorder may make you feel anxious most of the time, without any apparent reason. Or the anxious feelings may be so uncomfortable that, to avoid them, you may stop some everyday activities.
Most of the people in the studies had been diagnosed with at least one anxiety disorder such as agoraphobia‹a fear of having panic attacks in public places.
Researchers tracked how well they did on the kava or placebo using the Hamilton Anxiety Rating Scale (HAM-A), a standard tool used in testing anti-anxiety drugs. It measures how much a person anticipates the worst, feels tense, is fearful, has difficulty sleeping and concentrating, and suffers an array of other mental and physical problems. Normal scores are 17 or less, while 25 indicates a state of mild anxiety and 30 a state of moderate anxiety.
|THE BOTTOM LINE|
Kava seems to relieve some of the symptoms of clinical anxiety. According to a new unpublished study, it also relieves some of the stress of ordinary living.
There are no studies on the long-term safety of taking kava every day.
If you take kava, dont drink alcoholic beverages. If you take prescription drugs, check with your doctor before taking kava.
Dont take kava if youre under 18, are pregnant or nursing, or plan to operate heavy equipment, cautions the National Nutritional Foods Association, a health food and dietary supplement industry trade group.
The studies used 300 to 400 mg of kava extracts a day (they contained 210 to 240 mg of kavalactones, which many researchers think are kavas active ingredients). Four of the studies lasted four to eight weeks, the fifth one lasted 24 weeks.
In each, the kava-takers showed significant relief of their symptoms compared with the placebo-takers.
In the longest, conducted in 1997 at Jena University in Germany, the average HAM-A scores of the 52 men and women taking kava dropped from 31 to 10 after 24 weeks, while the scores of those taking the placebo dropped to 15.5
And, when the study ended, the participants showed no signs of dependency, unlike what often happens with prescription tranquilizers like Xanax.
But the study suffered from the same problem that muddies much of the research into drugs and mental state taking anything often makes people feel better. While three-quarters of the volunteers reported significant improvement when taking kava, so did half of those who took the (inactive) placebo. And at the conclusion of the study, nearly everyone no matter what they took reported feeling better than when the study began.
Whats more, these few kava studies are limited because they didnt rigorously control who participated in them, says the National Institute of Mental Healths Benedetto Vitiello. So its not really clear what the participants were suffering from‹whether it was just tension, fluctuating anxiety, or a true psychiatric problem.
Most of us dont suffer from clinical anxiety. But we do have to cope with the hassles and annoyances of daily life. Can kava help?
Only one study has looked. Its details they havent been reviewed or published in a scientific journal yet were released on the World Wide Web last April by the makers of Kavatrol, which was used in the research (www.natrol.com).
We looked at the effect of kava on the kind of stress you might suffer if your mother-in-law were coming to visit and the two of you didnt get along, says the studys principal investigator, Nirbhay Singh of Virginia Commonwealth University in Richmond.
Singh used the Daily Stress Inventory, which tracks the impact of relatively minor daily events that are perceived as stressful, annoying, or unpleasant like being stared at, having car trouble, or arguing with a spouse or mate.
Kavatrol relieved this kind of stress within a week and continued to work during the four weeks we studied it in 29 people who were suffering more than an average amount of stress, says Singh, who became familiar with kava in his native Fiji.
The 31 other over-stressed people who received a placebo found no relief, says Singh, who adds that he has submitted his research for publication in a scientific journal.
The more appropriate place for kava is if youre about to be prescribed a tranquilizer to treat your mild or moderate anxiety, says Jerry Cott of the National Institute of Mental Health.
You might discuss with your doctor trying kava first because it seems to work for some people and doesnt have the problems of dependence that most conventional anti-anxiety drugs do.
If you take kava, here are three things to watch out for:
Alcohol Kava may increase the effects of alcohol, so kava users shouldnt drink alcoholic beverages, advises Steven Dentali, a natural products pharmacologist who has reviewed the evidence on kavas safety for the herb industry. Some labels (Kavatrol, Soloray, and Natures Way, for example) carry a warning about alcohol. Others (like Country Life) dont.
Drug interactions Kava may also interact with prescription medications, cautions Dentali. In 1996, a Georgia man slipped in and out of consciousness a week after he began taking kava to wean himself off Xanax. His doctors blamed it on the kava-Xanax combination.6
The impact of kava on prescription drugs is the big, serious unknown about this herb, concedes Gary Friedman, who heads the Kava Committee, a consortium of kava-selling companies.
Safety Like most other dietary supplements, kava has not been tested to see if it causes cancer, birth defects, or other long-term safety problems.
1 Pharmacopsychiatry 22: 258,1989.
2 Fortschr. Med. 108: 49, 1990.
3 Fortschr. Med. 109: 119, 1991.
4 Phytomedicine 3: 113, 1996.
5 Pharmacopsychiatry 30: 1, 1997.
6 Ann. Intern. Med. 125: 940,1996.